Genesis 36:24
24 And these are the children of Zibeon; both Ajah, and Anah: this was that Anah that found the mules in the wilderness, as he fed the asses of Zibeon his father.
This was that Anah that found the mules. Mules are the adulterous offspring of the horse and the ass. Moses says that Anah was the author of this connection. But I do not consider this as said in praise of his industry; for the Lord has not in vain distinguished the different kinds of animals form the beginning. But since the vanity of the flesh often solicits the children of this world, so that they apply their minds to superfluous matters, Moses marks this unnatural pursuit in Anah, who did not think it sufficient to have a great number of animals; but he must add to them a degenerate race produced by unnatural intercourse. Moreover, we learn hence, that there is more moderation among brute animals in following the law of nature, than in men, who invent vicious admixtures.
— John Calvin (1509-1564)